Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 16111..16754 Replicon plasmid pL4FAA5_2
Accession NZ_CP115833
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag PGO70_RS26295 Protein ID WP_001044768.1
Coordinates 16111..16527 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag PGO70_RS26300 Protein ID WP_001261287.1
Coordinates 16524..16754 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS26260 (PGO70_26255) 11205..11459 - 255 WP_016528790.1 hypothetical protein -
PGO70_RS26265 (PGO70_26260) 11535..11792 - 258 WP_004098928.1 hypothetical protein -
PGO70_RS26270 (PGO70_26265) 11841..12044 - 204 WP_004150739.1 HHA domain-containing protein -
PGO70_RS26275 (PGO70_26270) 12105..12599 - 495 WP_016528789.1 hypothetical protein -
PGO70_RS26280 (PGO70_26275) 12630..13196 - 567 WP_009654312.1 hypothetical protein -
PGO70_RS26285 (PGO70_26280) 13193..13456 - 264 WP_009310051.1 hypothetical protein -
PGO70_RS26290 (PGO70_26285) 13811..15949 + 2139 WP_000350635.1 AAA family ATPase -
PGO70_RS26295 (PGO70_26290) 16111..16527 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
PGO70_RS26300 (PGO70_26295) 16524..16754 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PGO70_RS26305 (PGO70_26300) 17060..20179 + 3120 WP_032446663.1 hypothetical protein -
PGO70_RS26310 (PGO70_26305) 20442..21575 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - clbI / basG 1..95204 95204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T267414 WP_001044768.1 NZ_CP115833:c16527-16111 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT267414 WP_001261287.1 NZ_CP115833:c16754-16524 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References