Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1077451..1078100 Replicon chromosome
Accession NZ_CP115712
Organism Kosakonia pseudosacchari strain RX.G5M8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PF050_RS05165 Protein ID WP_086873680.1
Coordinates 1077451..1077813 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PF050_RS05170 Protein ID WP_271069498.1
Coordinates 1077801..1078100 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF050_RS05140 (PF050_05140) 1072789..1073793 - 1005 WP_271069495.1 LacI family DNA-binding transcriptional regulator -
PF050_RS05145 (PF050_05145) 1073833..1075692 - 1860 WP_271069496.1 beta-glucoside-specific PTS transporter subunit IIABC -
PF050_RS05150 (PF050_05150) 1075924..1076238 + 315 WP_097401500.1 antibiotic biosynthesis monooxygenase -
PF050_RS05155 (PF050_05155) 1076240..1076632 + 393 WP_271069497.1 amino acid-binding protein -
PF050_RS05160 (PF050_05160) 1076629..1077336 + 708 WP_271070112.1 winged helix-turn-helix domain-containing protein -
PF050_RS05165 (PF050_05165) 1077451..1077813 + 363 WP_086873680.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF050_RS05170 (PF050_05170) 1077801..1078100 + 300 WP_271069498.1 helix-turn-helix transcriptional regulator Antitoxin
PF050_RS05175 (PF050_05175) 1078106..1078540 + 435 WP_271069499.1 hypothetical protein -
PF050_RS05180 (PF050_05180) 1078681..1079448 + 768 WP_271069500.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
PF050_RS05185 (PF050_05185) 1079432..1080484 + 1053 WP_271069501.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
PF050_RS05190 (PF050_05190) 1080560..1082388 - 1829 Protein_1017 glycoside hydrolase family 15 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14143.30 Da        Isoelectric Point: 9.7915

>T267325 WP_086873680.1 NZ_CP115712:1077451-1077813 [Kosakonia pseudosacchari]
MWQVITTERFDVWFSIQPERLQDEILAVFRILSEFGPQLGRPYVDTVKGSTYSNMKELRIQYAGSPVRAFFAFDSTRRAI
VLCAGDKTGVNEKRFYKEMIKIADAEFRKHMRNKELTWQP

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11031.71 Da        Isoelectric Point: 7.0165

>AT267325 WP_271069498.1 NZ_CP115712:1077801-1078100 [Kosakonia pseudosacchari]
VATLDELLAKRSPESQARIEERVDELRRNIVLSQLREELNISQTELAVVMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GELSIDITLPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References