Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1142441..1143061 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PF325_RS05420 Protein ID WP_015571250.1
Coordinates 1142441..1142659 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PF325_RS05425 Protein ID WP_006809850.1
Coordinates 1142687..1143061 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS05390 (PF325_05390) 1138453..1138713 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
PF325_RS05395 (PF325_05395) 1138716..1138856 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PF325_RS05400 (PF325_05400) 1138853..1139563 - 711 WP_017383207.1 GNAT family protein -
PF325_RS05405 (PF325_05405) 1139665..1141125 + 1461 WP_172746071.1 PLP-dependent aminotransferase family protein -
PF325_RS05410 (PF325_05410) 1141097..1141564 - 468 WP_015571252.1 YlaC family protein -
PF325_RS05415 (PF325_05415) 1141681..1142232 - 552 WP_015571251.1 maltose O-acetyltransferase -
PF325_RS05420 (PF325_05420) 1142441..1142659 - 219 WP_015571250.1 HHA domain-containing protein Toxin
PF325_RS05425 (PF325_05425) 1142687..1143061 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PF325_RS05430 (PF325_05430) 1143572..1146718 - 3147 WP_271040581.1 multidrug efflux RND transporter permease subunit AcrB -
PF325_RS05435 (PF325_05435) 1146741..1147934 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T267267 WP_015571250.1 NZ_CP115689:c1142659-1142441 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT267267 WP_006809850.1 NZ_CP115689:c1143061-1142687 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References