Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 2842652..2843217 Replicon chromosome
Accession NZ_CP115671
Organism Brevundimonas vesicularis strain PL22-8A

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PFY01_RS14440 Protein ID WP_271041797.1
Coordinates 2842897..2843217 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1H1D608
Locus tag PFY01_RS14435 Protein ID WP_045809783.1
Coordinates 2842652..2842897 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFY01_RS14415 (PFY01_14415) 2837897..2838616 + 720 WP_271041793.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
PFY01_RS14420 (PFY01_14420) 2838818..2840179 + 1362 WP_271041794.1 glutamate--cysteine ligase -
PFY01_RS14425 (PFY01_14425) 2840176..2840913 - 738 WP_271041795.1 hypothetical protein -
PFY01_RS14430 (PFY01_14430) 2841026..2842597 + 1572 WP_271041796.1 ATP-binding protein -
PFY01_RS14435 (PFY01_14435) 2842652..2842897 + 246 WP_045809783.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PFY01_RS14440 (PFY01_14440) 2842897..2843217 + 321 WP_271041797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFY01_RS14445 (PFY01_14445) 2843214..2843963 + 750 WP_271041798.1 DUF72 domain-containing protein -
PFY01_RS14450 (PFY01_14450) 2844041..2845102 + 1062 WP_066549790.1 NAD(P)-dependent alcohol dehydrogenase -
PFY01_RS14455 (PFY01_14455) 2845246..2845971 + 726 WP_066549787.1 acetoacetyl-CoA reductase -
PFY01_RS14460 (PFY01_14460) 2846072..2846788 + 717 WP_271043074.1 DUF4908 domain-containing protein -
PFY01_RS14465 (PFY01_14465) 2846785..2847513 - 729 WP_271041799.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12006.51 Da        Isoelectric Point: 4.8728

>T267251 WP_271041797.1 NZ_CP115671:2842897-2843217 [Brevundimonas vesicularis]
MLRLSRAARADLQQVYLQGLELFGSRQADDYIEGLFAKLDLLADFPRLGAARPELSADAHVIFYKSHAILYRIDDADMFV
RRIRHALEDWQSDAPGVGSSDERSEP

Download         Length: 321 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9233.47 Da        Isoelectric Point: 7.0147

>AT267251 WP_045809783.1 NZ_CP115671:2842652-2842897 [Brevundimonas vesicularis]
MATMNISLPDPMKAWVEEQAKSGRYANTSDVVRDLIRREQVKAEKIAHWQRLIVEADASGVSDQSPREVIEELRAQLRRA
S

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H1D608

References