Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 873852..874477 Replicon chromosome
Accession NZ_CP115551
Organism Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PEE20_RS04300 Protein ID WP_151117435.1
Coordinates 874079..874477 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PEE20_RS04295 Protein ID WP_000557545.1
Coordinates 873852..874079 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEE20_RS04265 (868865) 868865..870382 + 1518 WP_000003339.1 lysine--tRNA ligase -
PEE20_RS04270 (870458) 870458..871003 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PEE20_RS04275 (871268) 871268..872026 + 759 WP_000244328.1 amidase activator ActS -
PEE20_RS04285 (872311) 872311..873117 - 807 WP_001574939.1 DUF1460 domain-containing protein -
PEE20_RS04290 (873392) 873392..873643 - 252 WP_001540858.1 hypothetical protein -
PEE20_RS04295 (873852) 873852..874079 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PEE20_RS04300 (874079) 874079..874477 + 399 WP_151117435.1 tRNA(fMet)-specific endonuclease VapC Toxin
PEE20_RS04305 (875288) 875288..875824 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PEE20_RS04310 (875871) 875871..876503 + 633 WP_000835265.1 YfdX family protein -
PEE20_RS04315 (877222) 877222..877809 + 588 WP_270805634.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 872311..900045 27734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15051.46 Da        Isoelectric Point: 7.7785

>T267174 WP_151117435.1 NZ_CP115551:874079-874477 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAIVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT267174 WP_000557545.1 NZ_CP115551:873852-874079 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References