Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 3407104..3408541 | Replicon | chromosome |
| Accession | NZ_CP114895 | ||
| Organism | Escherichia coli strain CM56 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | O6106_RS16745 | Protein ID | WP_000155570.1 |
| Coordinates | 3407104..3408177 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | O6106_RS16750 | Protein ID | WP_000461704.1 |
| Coordinates | 3408170..3408541 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O6106_RS16730 (3402537) | 3402537..3404726 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| O6106_RS16735 (3404723) | 3404723..3406339 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| O6106_RS16740 (3406699) | 3406699..3406962 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| O6106_RS16745 (3407104) | 3407104..3408177 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| O6106_RS16750 (3408170) | 3408170..3408541 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| O6106_RS16755 (3408896) | 3408896..3409759 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| O6106_RS16760 (3409851) | 3409851..3410672 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| O6106_RS16765 (3410889) | 3410889..3411590 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| O6106_RS16770 (3411631) | 3411631..3411867 | + | 237 | WP_001144029.1 | protein YpjK | - |
| O6106_RS16775 (3411867) | 3411867..3412310 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| O6106_RS16780 (3412334) | 3412334..3412801 | + | 468 | WP_000702495.1 | protein YfjT | - |
| O6106_RS16785 (3413188) | 3413188..3413340 | - | 153 | Protein_3259 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T267009 WP_000155570.1 NZ_CP114895:3407104-3408177 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT267009 WP_000461704.1 NZ_CP114895:3408170-3408541 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|