Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 1984809..1986246 | Replicon | chromosome |
| Accession | NZ_CP114892 | ||
| Organism | Escherichia coli strain CM5 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | O6Q95_RS09785 | Protein ID | WP_000155570.1 |
| Coordinates | 1984809..1985882 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | O6Q95_RS09790 | Protein ID | WP_000461704.1 |
| Coordinates | 1985875..1986246 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O6Q95_RS09770 (1980242) | 1980242..1982431 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| O6Q95_RS09775 (1982428) | 1982428..1984044 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| O6Q95_RS09780 (1984404) | 1984404..1984667 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| O6Q95_RS09785 (1984809) | 1984809..1985882 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| O6Q95_RS09790 (1985875) | 1985875..1986246 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| O6Q95_RS09795 (1986601) | 1986601..1987464 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| O6Q95_RS09800 (1987556) | 1987556..1988377 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| O6Q95_RS09805 (1988594) | 1988594..1989295 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| O6Q95_RS09810 (1989336) | 1989336..1989572 | + | 237 | WP_001144029.1 | protein YpjK | - |
| O6Q95_RS09815 (1989572) | 1989572..1990015 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| O6Q95_RS09820 (1990039) | 1990039..1990506 | + | 468 | WP_000702495.1 | protein YfjT | - |
| O6Q95_RS09825 (1990893) | 1990893..1991045 | - | 153 | Protein_1927 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T266927 WP_000155570.1 NZ_CP114892:1984809-1985882 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT266927 WP_000461704.1 NZ_CP114892:1985875-1986246 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|