Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4838514..4839772 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag O4M85_RS22620 Protein ID WP_019725936.1
Coordinates 4838514..4839269 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag O4M85_RS22625 Protein ID WP_003086329.1
Coordinates 4839404..4839772 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS22610 (O4M85_22610) 4833686..4836229 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
O4M85_RS22615 (O4M85_22615) 4836384..4837745 - 1362 WP_003081943.1 DNA recombination protein RmuC -
O4M85_RS22620 (O4M85_22620) 4838514..4839269 - 756 WP_019725936.1 RES family NAD+ phosphorylase Toxin
O4M85_RS22625 (O4M85_22625) 4839404..4839772 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
O4M85_RS22630 (O4M85_22630) 4839845..4841131 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
O4M85_RS22635 (O4M85_22635) 4841187..4842776 - 1590 WP_019725935.1 aldehyde dehydrogenase family protein -
O4M85_RS22640 (O4M85_22640) 4842855..4843331 + 477 WP_019725934.1 hypothetical protein -
O4M85_RS22645 (O4M85_22645) 4843334..4843609 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28192.33 Da        Isoelectric Point: 8.0554

>T266801 WP_019725936.1 NZ_CP114761:c4839269-4838514 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSGHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT266801 WP_003086329.1 NZ_CP114761:c4839772-4839404 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References