Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3791357..3792578 | Replicon | chromosome |
| Accession | NZ_CP114761 | ||
| Organism | Pseudomonas aeruginosa strain NF143349 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | O4M85_RS17350 | Protein ID | WP_003114949.1 |
| Coordinates | 3792000..3792578 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | O4M85_RS17345 | Protein ID | WP_003088112.1 |
| Coordinates | 3791357..3791911 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O4M85_RS17320 (O4M85_17320) | 3786925..3787476 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| O4M85_RS17325 (O4M85_17325) | 3787473..3787871 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| O4M85_RS17330 (O4M85_17330) | 3787884..3788207 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| O4M85_RS17335 (O4M85_17335) | 3788538..3788999 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| O4M85_RS17340 (O4M85_17340) | 3789004..3791199 | + | 2196 | WP_003450155.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| O4M85_RS17345 (O4M85_17345) | 3791357..3791911 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| O4M85_RS17350 (O4M85_17350) | 3792000..3792578 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| O4M85_RS17355 (O4M85_17355) | 3792686..3793873 | - | 1188 | WP_019726106.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| O4M85_RS17360 (O4M85_17360) | 3793863..3796034 | - | 2172 | WP_031642042.1 | type I secretion system permease/ATPase | - |
| O4M85_RS17365 (O4M85_17365) | 3796024..3797301 | - | 1278 | WP_019726104.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T266800 WP_003114949.1 NZ_CP114761:3792000-3792578 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT266800 WP_003088112.1 NZ_CP114761:3791357-3791911 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|