Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3791357..3792578 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O4M85_RS17350 Protein ID WP_003114949.1
Coordinates 3792000..3792578 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag O4M85_RS17345 Protein ID WP_003088112.1
Coordinates 3791357..3791911 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS17320 (O4M85_17320) 3786925..3787476 + 552 WP_003132721.1 XRE family transcriptional regulator -
O4M85_RS17325 (O4M85_17325) 3787473..3787871 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
O4M85_RS17330 (O4M85_17330) 3787884..3788207 - 324 WP_003102734.1 multidrug efflux SMR transporter -
O4M85_RS17335 (O4M85_17335) 3788538..3788999 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
O4M85_RS17340 (O4M85_17340) 3789004..3791199 + 2196 WP_003450155.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
O4M85_RS17345 (O4M85_17345) 3791357..3791911 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
O4M85_RS17350 (O4M85_17350) 3792000..3792578 + 579 WP_003114949.1 HD domain-containing protein Toxin
O4M85_RS17355 (O4M85_17355) 3792686..3793873 - 1188 WP_019726106.1 HlyD family efflux transporter periplasmic adaptor subunit -
O4M85_RS17360 (O4M85_17360) 3793863..3796034 - 2172 WP_031642042.1 type I secretion system permease/ATPase -
O4M85_RS17365 (O4M85_17365) 3796024..3797301 - 1278 WP_019726104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T266800 WP_003114949.1 NZ_CP114761:3792000-3792578 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT266800 WP_003088112.1 NZ_CP114761:3791357-3791911 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References