Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5169522..5171203 | Replicon | chromosome |
| Accession | NZ_CP114332 | ||
| Organism | Klebsiella variicola strain 2022CK-00505 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A1F2M1V2 |
| Locus tag | OGU18_RS25075 | Protein ID | WP_032734038.1 |
| Coordinates | 5169522..5170439 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | OGU18_RS25080 | Protein ID | WP_110242892.1 |
| Coordinates | 5170445..5171203 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OGU18_RS25055 (OGU18_25050) | 5164828..5166348 | + | 1521 | WP_110242893.1 | sugar ABC transporter ATP-binding protein | - |
| OGU18_RS25060 (OGU18_25055) | 5166345..5167343 | + | 999 | WP_023296904.1 | ribose ABC transporter permease | - |
| OGU18_RS25065 (OGU18_25060) | 5167374..5168315 | + | 942 | WP_012543155.1 | ABC transporter substrate-binding protein | - |
| OGU18_RS25070 (OGU18_25065) | 5168390..5169397 | + | 1008 | WP_022065799.1 | carbohydrate kinase family protein | - |
| OGU18_RS25075 (OGU18_25070) | 5169522..5170439 | - | 918 | WP_032734038.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OGU18_RS25080 (OGU18_25075) | 5170445..5171203 | - | 759 | WP_110242892.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| OGU18_RS25085 (OGU18_25080) | 5171288..5172016 | - | 729 | WP_008807258.1 | response regulator transcription factor | - |
| OGU18_RS25090 (OGU18_25085) | 5172289..5174436 | + | 2148 | WP_077625453.1 | formate dehydrogenase subunit alpha | - |
| OGU18_RS25095 (OGU18_25090) | 5174790..5175476 | + | 687 | WP_008807260.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34733.10 Da Isoelectric Point: 5.4707
>T266585 WP_032734038.1 NZ_CP114332:c5170439-5169522 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28657.94 Da Isoelectric Point: 10.1988
>AT266585 WP_110242892.1 NZ_CP114332:c5171203-5170445 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|