Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1914112..1914663 Replicon chromosome
Accession NZ_CP114328
Organism Klebsiella variicola strain 2022CK-00504

Toxin (Protein)


Gene name pemK Uniprot ID A0A2V3KRZ7
Locus tag OEE49_RS09250 Protein ID WP_046881584.1
Coordinates 1914112..1914444 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A2V3KU66
Locus tag OEE49_RS09255 Protein ID WP_046881585.1
Coordinates 1914445..1914663 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE49_RS09220 (OEE49_09220) 1909878..1910978 - 1101 WP_070612302.1 AarF/UbiB family protein -
OEE49_RS09225 (OEE49_09225) 1911505..1911762 + 258 WP_012541132.1 antitoxin -
OEE49_RS09230 (OEE49_09230) 1911763..1912095 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin -
OEE49_RS09240 (OEE49_09240) 1912418..1913854 + 1437 WP_269136626.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OEE49_RS09250 (OEE49_09250) 1914112..1914444 - 333 WP_046881584.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OEE49_RS09255 (OEE49_09255) 1914445..1914663 - 219 WP_046881585.1 antitoxin Antitoxin
OEE49_RS09260 (OEE49_09260) 1914975..1915955 - 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
OEE49_RS09265 (OEE49_09265) 1916051..1917985 + 1935 WP_046881586.1 P-loop NTPase fold protein -
OEE49_RS09270 (OEE49_09270) 1917985..1918851 + 867 WP_046881587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1914975..1915955 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11751.64 Da        Isoelectric Point: 10.8919

>T266558 WP_046881584.1 NZ_CP114328:c1914444-1914112 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKAAFNKQTRLPVVVPVTSGGNFARATGFTVSLDGVGTKTTGVLRCDQPRTI
VMGARSGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7877.07 Da        Isoelectric Point: 4.1364

>AT266558 WP_046881585.1 NZ_CP114328:c1914663-1914445 [Klebsiella variicola]
MLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGREWIDAPAVGKEIM

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KRZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KU66

References