Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2533308..2533779 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag N0F11_RS12695 Protein ID WP_001303511.1
Coordinates 2533501..2533779 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag N0F11_RS12690 Protein ID WP_001302048.1
Coordinates 2533308..2533499 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS12650 (2528515) 2528515..2529099 - 585 WP_000206793.1 DUF551 domain-containing protein -
N0F11_RS12655 (2529156) 2529156..2529551 - 396 WP_001118159.1 DUF977 family protein -
N0F11_RS12660 (2529567) 2529567..2530336 - 770 Protein_2479 DUF1627 domain-containing protein -
N0F11_RS12665 (2530362) 2530362..2531102 - 741 WP_000788938.1 ATP-binding protein -
N0F11_RS12670 (2531109) 2531109..2532071 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
N0F11_RS12675 (2532094) 2532094..2532519 - 426 WP_000693943.1 toxin YdaT family protein -
N0F11_RS12680 (2532516) 2532516..2532818 - 303 WP_000172738.1 transcriptional regulator -
N0F11_RS12685 (2532916) 2532916..2533287 + 372 WP_001169686.1 hypothetical protein -
N0F11_RS12690 (2533308) 2533308..2533499 + 192 WP_001302048.1 hypothetical protein Antitoxin
N0F11_RS12695 (2533501) 2533501..2533779 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0F11_RS12700 (2534132) 2534132..2534431 + 300 WP_001240334.1 hypothetical protein -
N0F11_RS12705 (2534503) 2534503..2534721 + 219 WP_001171930.1 protein YdfC -
N0F11_RS12710 (2535287) 2535287..2535475 + 189 WP_000449192.1 cell division inhibition protein DicB -
N0F11_RS12715 (2535472) 2535472..2535666 + 195 WP_269134748.1 DUF1482 family protein -
N0F11_RS12720 (2535759) 2535759..2538230 + 2472 WP_269134749.1 exonuclease -
N0F11_RS12725 (2538295) 2538295..2538543 + 249 WP_000113189.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2443203..2543786 100583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T266304 WP_001303511.1 NZ_CP114130:2533501-2533779 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT266304 WP_001302048.1 NZ_CP114130:2533308-2533499 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References