Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 351811..352327 Replicon plasmid pA
Accession NZ_CP113799
Organism Rhodococcus pyridinivorans strain P23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OQN32_RS25845 Protein ID WP_139000135.1
Coordinates 351811..352068 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag OQN32_RS25850 Protein ID WP_139000136.1
Coordinates 352070..352327 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQN32_RS25830 (OQN32_25830) 347567..348481 - 915 WP_268655830.1 ABC transporter substrate-binding protein -
OQN32_RS25835 (OQN32_25835) 349713..350180 + 468 Protein_291 transposase -
OQN32_RS25840 (OQN32_25840) 350474..351453 - 980 Protein_292 IS481 family transposase -
OQN32_RS25845 (OQN32_25845) 351811..352068 - 258 WP_139000135.1 Txe/YoeB family addiction module toxin Toxin
OQN32_RS25850 (OQN32_25850) 352070..352327 - 258 WP_139000136.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OQN32_RS25855 (OQN32_25855) 352380..352535 + 156 Protein_295 plasmid pRiA4b ORF-3 family protein -
OQN32_RS25860 (OQN32_25860) 352826..353777 + 952 Protein_296 transposase -
OQN32_RS25865 (OQN32_25865) 353956..354153 + 198 WP_139000137.1 DUF1778 domain-containing protein -
OQN32_RS25870 (OQN32_25870) 354150..354527 + 378 WP_139000138.1 type II toxin-antitoxin system death-on-curing family toxin -
OQN32_RS25875 (OQN32_25875) 355136..355279 - 144 WP_268655831.1 hypothetical protein -
OQN32_RS25880 (OQN32_25880) 355437..355790 + 354 WP_268655832.1 hypothetical protein -
OQN32_RS25885 (OQN32_25885) 355880..356017 + 138 WP_240795125.1 hypothetical protein -
OQN32_RS25890 (OQN32_25890) 356078..356950 + 873 WP_139000139.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..580882 580882
- inside IScluster/Tn - - 350474..353777 3303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10357.77 Da        Isoelectric Point: 8.0063

>T266066 WP_139000135.1 NZ_CP113799:c352068-351811 [Rhodococcus pyridinivorans]
MLLVWDENAWQDYLWWQQQDRKILKRINTLLVDIQRNGNEGIGKPEPLKYDFAGYWSRRITDEHRLVYKVTDTEVRIAAC
RYHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9615.77 Da        Isoelectric Point: 4.8616

>AT266066 WP_139000136.1 NZ_CP113799:c352327-352070 [Rhodococcus pyridinivorans]
VKTMSYTESRARYAEVLDAVTNDREEVIITRAGHEPVVMVSLDDYESLRETAHLMRSPANARRLLDAMERLEAGRGQSHS
LLDVD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References