Detailed information of TA system TA265979

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3612209..3612641
• Replicon: chromosome
• Accession: NZ_CP113539
• Organism: Salmonella enterica strain FFL

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5H8VGI7
• Locus tag: OXV09_RS17620
• Protein ID: WP_058805824.1
• Coordinates: 3612366..3612641 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3612209..3612590 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OXV09_RS17590	3607472..3607966	-	495	WP_187788956.1	pilus assembly protein	-
OXV09_RS17595	3608731..3609432	-	702	Protein_3445	integrase core domain-containing protein	-
OXV09_RS17600	3609485..3609799	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
OXV09_RS17605	3609866..3610144	-	279	WP_077905025.1	hypothetical protein	-
OXV09_RS17610	3610460..3610927	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
OXV09_RS17615	3611799..3612032	-	234	WP_129374720.1	hypothetical protein	-
-	3612209..3612590	-	382	-	-	Antitoxin
OXV09_RS17620	3612366..3612641	+	276	WP_058805824.1	SymE family type I addiction module toxin	Toxin
OXV09_RS17625	3612686..3613003	-	318	WP_129374721.1	hypothetical protein	-
OXV09_RS17630	3612969..3614252	-	1284	Protein_3452	RHS domain-containing protein	-
OXV09_RS17635	3614389..3614853	-	465	WP_223152163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3602398..3640533	38135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9901.27 Da
• Isoelectric Point: 5.0770

>T265979 WP_058805824.1 NZ_CP113539:3612366-3612641 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLTLIAERDEVQELREELYQVKQVVKGM
KVGISGVLREV

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 382 bp

>AT265979 NZ_CP113539:c3612590-3612209 [Salmonella enterica]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5H8VGI7

Antitoxin