Detailed information of TA system TA265945

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3544921..3545343
• Replicon: chromosome
• Accession: NZ_CP113537
• Organism: Salmonella enterica strain YZY

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: OXV04_RS17090
• Protein ID: WP_023232369.1
• Coordinates: 3545068..3545343 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3544921..3545333 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OXV04_RS17055	3540182..3540676	-	495	WP_126524259.1	hypothetical protein	-
OXV04_RS17060	3541436..3542137	-	702	Protein_3337	integrase core domain-containing protein	-
OXV04_RS17065	3542190..3542504	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
OXV04_RS17070	3542571..3542849	-	279	WP_077905025.1	hypothetical protein	-
OXV04_RS17075	3543165..3543632	-	468	WP_063809038.1	hypothetical protein	-
OXV04_RS17080	3543629..3544000	-	372	WP_225872841.1	hypothetical protein	-
OXV04_RS17085	3544450..3544743	-	294	WP_225872842.1	hypothetical protein	-
-	3544921..3545333	-	413	-	-	Antitoxin
OXV04_RS17090	3545068..3545343	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
OXV04_RS17095	3545400..3545732	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3522350..3545732	23382
	-	flank	IS/Tn	-	-	3541436..3541714	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T265945 WP_023232369.1 NZ_CP113537:3545068-3545343 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT265945 NZ_CP113537:c3545333-3544921 [Salmonella enterica]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin