Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1851312..1851902 Replicon chromosome
Accession NZ_CP113537
Organism Salmonella enterica strain YZY

Toxin (Protein)


Gene name pemK Uniprot ID A0A3S5G4X7
Locus tag OXV04_RS08685 Protein ID WP_039591092.1
Coordinates 1851570..1851902 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3V3TWU4
Locus tag OXV04_RS08680 Protein ID WP_039520052.1
Coordinates 1851312..1851569 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV04_RS08665 (1848640) 1848640..1849902 - 1263 WP_206612204.1 hypothetical protein -
OXV04_RS08670 (1850288) 1850288..1850761 + 474 WP_126523999.1 hypothetical protein -
OXV04_RS08675 (1850758) 1850758..1850964 + 207 WP_268651589.1 helix-turn-helix transcriptional regulator -
OXV04_RS08680 (1851312) 1851312..1851569 + 258 WP_039520052.1 antitoxin Antitoxin
OXV04_RS08685 (1851570) 1851570..1851902 + 333 WP_039591092.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OXV04_RS08690 (1852735) 1852735..1853619 + 885 WP_126524002.1 integrase domain-containing protein -
OXV04_RS08695 (1854649) 1854649..1855911 - 1263 WP_126524003.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1841548..1851902 10354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11765.62 Da        Isoelectric Point: 10.5834

>T265939 WP_039591092.1 NZ_CP113537:1851570-1851902 [Salmonella enterica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARAAGFTVSLEGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9370.85 Da        Isoelectric Point: 4.4488

>AT265939 WP_039520052.1 NZ_CP113537:1851312-1851569 [Salmonella enterica]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5G4X7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V3TWU4

References