Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4146860..4147118 Replicon chromosome
Accession NZ_CP113503
Organism Escherichia coli strain 16843

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag OWO50_RS19865 Protein ID WP_000809168.1
Coordinates 4146966..4147118 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4146860..4146917 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OWO50_RS19850 4142689..4143948 - 1260 WP_000494927.1 hypothetical protein -
OWO50_RS19855 4144077..4145570 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
OWO50_RS19860 4145590..4146351 - 762 WP_001274828.1 outer membrane protein OmpK -
- 4146860..4146917 - 58 - - Antitoxin
OWO50_RS19865 4146966..4147118 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
OWO50_RS19870 4147223..4148353 - 1131 WP_001118464.1 molecular chaperone DnaJ -
OWO50_RS19875 4148442..4150358 - 1917 WP_000516135.1 molecular chaperone DnaK -
OWO50_RS19880 4150730..4151134 + 405 WP_000843689.1 DUF2541 family protein -
OWO50_RS19885 4151160..4151873 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T265831 WP_000809168.1 NZ_CP113503:4146966-4147118 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT265831 NZ_CP113503:c4146917-4146860 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References