Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2985498..2986100 Replicon chromosome
Accession NZ_CP113486
Organism Escherichia coli strain GTEN_23

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag FG550_RS14380 Protein ID WP_000897305.1
Coordinates 2985498..2985809 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FG550_RS14385 Protein ID WP_000356395.1
Coordinates 2985810..2986100 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG550_RS14355 (2980540) 2980540..2980977 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
FG550_RS14360 (2981022) 2981022..2981963 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
FG550_RS14365 (2982379) 2982379..2983266 + 888 Protein_2806 hypothetical protein -
FG550_RS14370 (2983279) 2983279..2984193 + 915 WP_109553727.1 transposase -
FG550_RS14375 (2984361) 2984361..2985269 - 909 WP_001550353.1 alpha/beta hydrolase -
FG550_RS14380 (2985498) 2985498..2985809 + 312 WP_000897305.1 hypothetical protein Toxin
FG550_RS14385 (2985810) 2985810..2986100 + 291 WP_000356395.1 NadS family protein Antitoxin
FG550_RS14390 (2986185) 2986185..2986406 + 222 WP_001550354.1 hypothetical protein -
FG550_RS14395 (2986458) 2986458..2986736 + 279 WP_001315112.1 hypothetical protein -
FG550_RS14400 (2987155) 2987155..2987373 + 219 WP_001295676.1 CopG family transcriptional regulator -
FG550_RS14405 (2987592) 2987592..2987834 + 243 WP_001309881.1 CopG family transcriptional regulator -
FG550_RS14410 (2988016) 2988016..2988945 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
FG550_RS14415 (2988942) 2988942..2989577 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
FG550_RS14420 (2989574) 2989574..2990476 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T265754 WP_000897305.1 NZ_CP113486:2985498-2985809 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT265754 WP_000356395.1 NZ_CP113486:2985810-2986100 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References