Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1033621..1034216 Replicon chromosome
Accession NZ_CP113246
Organism Pseudomonas aeruginosa strain SMC4386

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag OUY23_RS04715 Protein ID WP_003117425.1
Coordinates 1033621..1033899 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OUY23_RS04720 Protein ID WP_003113527.1
Coordinates 1033911..1034216 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUY23_RS04695 (OUY23_04695) 1029047..1030285 + 1239 WP_003113524.1 dipeptidase -
OUY23_RS04700 (OUY23_04700) 1030347..1030994 + 648 WP_003095021.1 carbonate dehydratase -
OUY23_RS04705 (OUY23_04705) 1031064..1033292 - 2229 WP_003113525.1 TonB-dependent receptor -
OUY23_RS04710 (OUY23_04710) 1033440..1033568 + 129 Protein_923 integrase -
OUY23_RS04715 (OUY23_04715) 1033621..1033899 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OUY23_RS04720 (OUY23_04720) 1033911..1034216 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
OUY23_RS04725 (OUY23_04725) 1034553..1034945 + 393 WP_052155873.1 hypothetical protein -
OUY23_RS04730 (OUY23_04730) 1035336..1036574 + 1239 WP_141265240.1 hypothetical protein -
OUY23_RS04735 (OUY23_04735) 1036589..1037599 + 1011 WP_141265242.1 hypothetical protein -
OUY23_RS04740 (OUY23_04740) 1037544..1038158 + 615 WP_141265244.1 hypothetical protein -
OUY23_RS04745 (OUY23_04745) 1038178..1038513 - 336 WP_058876602.1 hypothetical protein -
OUY23_RS04750 (OUY23_04750) 1038569..1038835 - 267 WP_023088595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T265654 WP_003117425.1 NZ_CP113246:1033621-1033899 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT265654 WP_003113527.1 NZ_CP113246:1033911-1034216 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References