Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4755514..4756030 Replicon chromosome
Accession NZ_CP113178
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OT490_RS22925 Protein ID WP_004178374.1
Coordinates 4755514..4755798 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT490_RS22930 Protein ID WP_002886901.1
Coordinates 4755788..4756030 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS22900 (4750998) 4750998..4751261 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
OT490_RS22905 (4751391) 4751391..4751564 + 174 WP_032408826.1 hypothetical protein -
OT490_RS22910 (4751567) 4751567..4752310 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT490_RS22915 (4752667) 4752667..4754805 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT490_RS22920 (4755046) 4755046..4755510 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT490_RS22925 (4755514) 4755514..4755798 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT490_RS22930 (4755788) 4755788..4756030 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT490_RS22935 (4756108) 4756108..4758018 - 1911 WP_004178373.1 PRD domain-containing protein -
OT490_RS22940 (4758041) 4758041..4759195 - 1155 WP_004178372.1 lactonase family protein -
OT490_RS22945 (4759262) 4759262..4760002 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T265511 WP_004178374.1 NZ_CP113178:c4755798-4755514 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265511 WP_002886901.1 NZ_CP113178:c4756030-4755788 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References