Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2645966..2647187 Replicon chromosome
Accession NZ_CP113106
Organism Pseudomonas aeruginosa strain BIAI 157

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OSZ59_RS12260 Protein ID WP_003114949.1
Coordinates 2646609..2647187 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OSZ59_RS12255 Protein ID WP_034073312.1
Coordinates 2645966..2646520 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ59_RS12230 (OSZ59_12230) 2641534..2642085 + 552 WP_003132721.1 XRE family transcriptional regulator -
OSZ59_RS12235 (OSZ59_12235) 2642082..2642480 - 399 WP_031756111.1 NADH-quinone oxidoreductase subunit A -
OSZ59_RS12240 (OSZ59_12240) 2642493..2642816 - 324 WP_003102734.1 multidrug efflux SMR transporter -
OSZ59_RS12245 (OSZ59_12245) 2643147..2643608 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
OSZ59_RS12250 (OSZ59_12250) 2643613..2645808 + 2196 WP_016263578.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OSZ59_RS12255 (OSZ59_12255) 2645966..2646520 + 555 WP_034073312.1 helix-turn-helix transcriptional regulator Antitoxin
OSZ59_RS12260 (OSZ59_12260) 2646609..2647187 + 579 WP_003114949.1 HD domain-containing protein Toxin
OSZ59_RS12265 (OSZ59_12265) 2647295..2648482 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OSZ59_RS12270 (OSZ59_12270) 2648472..2650643 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
OSZ59_RS12275 (OSZ59_12275) 2650633..2651910 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-61)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T265422 WP_003114949.1 NZ_CP113106:2646609-2647187 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20412.55 Da        Isoelectric Point: 8.1590

>AT265422 WP_034073312.1 NZ_CP113106:2645966-2646520 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLGEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References