Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1929119..1930755 Replicon chromosome
Accession NZ_CP113071
Organism Acinetobacter baumannii strain A118 DeltaH0N27_10830::kan

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B4MZ76
Locus tag OSH14_RS09095 Protein ID WP_000737058.1
Coordinates 1929424..1930755 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OSH14_RS09090 Protein ID WP_001101310.1
Coordinates 1929119..1929427 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSH14_RS09065 (OSH14_09065) 1924660..1925178 - 519 WP_168726233.1 GNAT family N-acetyltransferase -
OSH14_RS09070 (OSH14_09070) 1925356..1926192 - 837 WP_168726232.1 SIR2 family protein -
OSH14_RS09075 (OSH14_09075) 1926189..1926731 - 543 WP_168726231.1 non-canonical purine NTP pyrophosphatase -
OSH14_RS09080 (OSH14_09080) 1926732..1927730 - 999 WP_168726230.1 adenosine deaminase -
OSH14_RS09085 (OSH14_09085) 1927848..1928396 - 549 WP_168726229.1 TetR/AcrR family transcriptional regulator -
OSH14_RS09090 (OSH14_09090) 1929119..1929427 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OSH14_RS09095 (OSH14_09095) 1929424..1930755 - 1332 WP_000737058.1 HipA domain-containing protein Toxin
OSH14_RS09100 (OSH14_09100) 1931051..1931491 + 441 WP_168726228.1 HD domain-containing protein -
OSH14_RS09105 (OSH14_09105) 1931526..1932170 - 645 WP_032000318.1 hypothetical protein -
OSH14_RS09110 (OSH14_09110) 1932182..1933153 - 972 WP_168726227.1 5'/3'-nucleotidase SurE -
OSH14_RS09115 (OSH14_09115) 1933280..1934443 - 1164 WP_168726226.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51202.34 Da        Isoelectric Point: 4.9820

>T265354 WP_000737058.1 NZ_CP113071:c1930755-1929424 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT265354 WP_001101310.1 NZ_CP113071:c1929427-1929119 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4MZ76

Antitoxin

Source ID Structure

References