Detailed information of TA system TA265269

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2740970..2741549
• Replicon: chromosome
• Accession: NZ_CP113039
• Organism: Staphylococcus aureus strain Gwen

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OS086_RS13755
• Protein ID: WP_001025401.1
• Coordinates: 2741304..2741549 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2740970..2741335 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS086_RS13715 (2737714)	2737714..2738271	-	558	WP_000645045.1	DUF2815 family protein	-
OS086_RS13720 (2738297)	2738297..2739463	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
OS086_RS13725 (2739460)	2739460..2739822	-	363	WP_000279445.1	hypothetical protein	-
OS086_RS13730 (2739837)	2739837..2740160	-	324	WP_000174995.1	hypothetical protein	-
OS086_RS13735 (2740239)	2740239..2740400	-	162	WP_015986189.1	DUF1270 family protein	-
OS086_RS13740 (2740412)	2740412..2740675	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
OS086_RS13745 (2740700)	2740700..2740915	-	216	WP_001097552.1	hypothetical protein	-
OS086_RS13750 (2740970)	2740970..2741335	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OS086_RS13755 (2741304)	2741304..2741549	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OS086_RS13760 (2741605)	2741605..2741814	+	210	WP_000642492.1	hypothetical protein	-
OS086_RS13765 (2741804)	2741804..2741947	-	144	WP_000939498.1	hypothetical protein	-
OS086_RS13770 (2741978)	2741978..2742172	-	195	WP_001148857.1	hypothetical protein	-
OS086_RS13775 (2742189)	2742189..2742744	-	556	Protein_2678	phage antirepressor KilAC domain-containing protein	-
OS086_RS13780 (2742770)	2742770..2742997	-	228	WP_001030311.1	hypothetical protein	-
OS086_RS13785 (2743169)	2743169..2743783	+	615	WP_000801423.1	XRE family transcriptional regulator	-
OS086_RS13790 (2743799)	2743799..2744719	+	921	WP_000348133.1	exonuclease domain-containing protein	-
OS086_RS13795 (2744815)	2744815..2744997	+	183	WP_000705240.1	hypothetical protein	-
OS086_RS13800 (2745033)	2745033..2745179	+	147	WP_267811058.1	hypothetical protein	-
OS086_RS13805 (2745176)	2745176..2745790	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2701279..2759873	58594

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T265269 WP_001025401.1 NZ_CP113039:c2741549-2741304 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT265269 NZ_CP113039:2740970-2741335 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin