Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2350459..2351154 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag ORO19_RS10965 Protein ID WP_003410811.1
Coordinates 2350459..2350893 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag ORO19_RS10970 Protein ID WP_003410814.1
Coordinates 2350900..2351154 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS10955 (ORO19_10955) 2346613..2349654 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
ORO19_RS10960 (ORO19_10960) 2349647..2350480 + 834 WP_003899172.1 SWIM zinc finger family protein -
ORO19_RS10965 (ORO19_10965) 2350459..2350893 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS10970 (ORO19_10970) 2350900..2351154 - 255 WP_003410814.1 antitoxin Antitoxin
ORO19_RS10975 (ORO19_10975) 2351170..2351427 - 258 WP_003410816.1 hypothetical protein -
ORO19_RS10980 (ORO19_10980) 2352374..2352670 + 297 WP_003410820.1 PE family protein -
ORO19_RS10985 (ORO19_10985) 2352726..2353457 + 732 WP_003900467.1 PPE family protein -
ORO19_RS10990 (ORO19_10990) 2353997..2354743 - 747 WP_003901330.1 proteasome subunit alpha -
ORO19_RS10995 (ORO19_10995) 2354740..2355615 - 876 WP_003411023.1 proteasome subunit beta -
ORO19_RS11000 (ORO19_11000) 2355612..2355806 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T265020 WP_003410811.1 NZ_CP112996:c2350893-2350459 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT265020 WP_003410814.1 NZ_CP112996:c2351154-2350900 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References