Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2190809..2191512 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag ORO19_RS10170 Protein ID WP_003409778.1
Coordinates 2190809..2191138 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag ORO19_RS10175 Protein ID WP_003409780.1
Coordinates 2191135..2191512 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS10150 (ORO19_10150) 2187192..2188262 + 1071 WP_003899091.1 epoxide hydrolase EphB -
ORO19_RS10155 (ORO19_10155) 2188259..2188774 + 516 WP_003409718.1 flavin reductase family protein -
ORO19_RS10160 (ORO19_10160) 2188771..2189832 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
ORO19_RS10165 (ORO19_10165) 2189829..2190599 + 771 WP_003409775.1 SDR family oxidoreductase -
ORO19_RS10170 (ORO19_10170) 2190809..2191138 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ORO19_RS10175 (ORO19_10175) 2191135..2191512 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
ORO19_RS10180 (ORO19_10180) 2191509..2192099 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
ORO19_RS10185 (ORO19_10185) 2192154..2193518 + 1365 WP_003899094.1 HNH endonuclease signature motif containing protein -
ORO19_RS10190 (ORO19_10190) 2193673..2194125 - 453 WP_010950636.1 lipoprotein -
ORO19_RS10195 (ORO19_10195) 2194189..2194590 + 402 WP_003409869.1 hypothetical protein -
ORO19_RS10200 (ORO19_10200) 2194583..2194765 - 183 WP_003409870.1 hypothetical protein -
ORO19_RS10205 (ORO19_10205) 2194879..2195229 - 351 WP_003409871.1 hypothetical protein -
ORO19_RS10210 (ORO19_10210) 2195240..2196142 - 903 WP_003409874.1 hypothetical protein -
ORO19_RS10215 (ORO19_10215) 2196163..2196354 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T265011 WP_003409778.1 NZ_CP112996:c2191138-2190809 [Mycobacterium tuberculosis variant bovis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT265011 WP_003409780.1 NZ_CP112996:c2191512-2191135 [Mycobacterium tuberculosis variant bovis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References