Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1024737..1025710 | Replicon | chromosome |
| Accession | NZ_CP112996 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain 2018/0565 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | O05911 |
| Locus tag | ORO19_RS04880 | Protein ID | WP_003404756.1 |
| Coordinates | 1025210..1025710 (+) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | G0TFR4 |
| Locus tag | ORO19_RS04875 | Protein ID | WP_003404754.1 |
| Coordinates | 1024737..1025213 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ORO19_RS04855 (ORO19_04855) | 1020584..1021855 | - | 1272 | WP_003404747.1 | PPE family protein | - |
| ORO19_RS04860 (ORO19_04860) | 1021870..1022169 | - | 300 | WP_003404748.1 | PE family protein | - |
| ORO19_RS04865 (ORO19_04865) | 1022613..1024394 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
| ORO19_RS04870 (ORO19_04870) | 1024394..1024648 | + | 255 | WP_003898646.1 | hypothetical protein | - |
| ORO19_RS04875 (ORO19_04875) | 1024737..1025213 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
| ORO19_RS04880 (ORO19_04880) | 1025210..1025710 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
| ORO19_RS04890 (ORO19_04890) | 1026023..1027342 | - | 1320 | WP_010950468.1 | IS256-like element IS1554 family transposase | - |
| ORO19_RS04895 (ORO19_04895) | 1027630..1028211 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
| ORO19_RS04900 (ORO19_04900) | 1028211..1029863 | + | 1653 | WP_003404761.1 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1024391..1070304 | 45913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T264999 WP_003404756.1 NZ_CP112996:1025210-1025710 [Mycobacterium tuberculosis variant bovis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT264999 WP_003404754.1 NZ_CP112996:1024737-1025213 [Mycobacterium tuberculosis variant bovis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TFR4 |