Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 678855..679474 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag ORO19_RS03075 Protein ID WP_003403047.1
Coordinates 679067..679474 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag ORO19_RS03070 Protein ID WP_003403039.1
Coordinates 678855..679070 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS03060 (ORO19_03060) 677383..678141 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
ORO19_RS03065 (ORO19_03065) 678270..678761 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
ORO19_RS03070 (ORO19_03070) 678855..679070 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
ORO19_RS03075 (ORO19_03075) 679067..679474 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
ORO19_RS03080 (ORO19_03080) 679534..680220 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
ORO19_RS03085 (ORO19_03085) 680374..683007 + 2634 WP_010950416.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T264986 WP_003403047.1 NZ_CP112996:679067-679474 [Mycobacterium tuberculosis variant bovis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT264986 WP_003403039.1 NZ_CP112996:678855-679070 [Mycobacterium tuberculosis variant bovis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References