Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 449118..449773 Replicon chromosome
Accession NZ_CP111136
Organism Burkholderia pseudomallei strain MSHR7744

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OSB53_RS02270 Protein ID WP_004521942.1
Coordinates 449477..449773 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag OSB53_RS02265 Protein ID WP_004202809.1
Coordinates 449118..449474 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB53_RS02235 (OSB53_02235) 445244..446002 + 759 WP_004521940.1 cytochrome c1 -
OSB53_RS02240 (OSB53_02240) 446095..446706 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
OSB53_RS02245 (OSB53_02245) 446776..447303 + 528 WP_004521941.1 ClpXP protease specificity-enhancing factor -
OSB53_RS02255 (OSB53_02255) 447639..448022 + 384 WP_044584020.1 terminase -
OSB53_RS02260 (OSB53_02260) 448019..449074 + 1056 WP_004557286.1 phage portal protein -
OSB53_RS02265 (OSB53_02265) 449118..449474 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
OSB53_RS02270 (OSB53_02270) 449477..449773 - 297 WP_004521942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSB53_RS02275 (OSB53_02275) 450441..451697 + 1257 WP_004552667.1 AAA family ATPase -
OSB53_RS02280 (OSB53_02280) 451742..452317 + 576 WP_198014201.1 DUF4276 family protein -
OSB53_RS02285 (OSB53_02285) 453071..453415 + 345 WP_004535737.1 hypothetical protein -
OSB53_RS02290 (OSB53_02290) 453408..453819 + 412 Protein_445 phage tail protein I -
OSB53_RS02295 (OSB53_02295) 453858..454319 + 462 WP_232290550.1 DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 447708..455775 8067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10902.68 Da        Isoelectric Point: 9.9369

>T264869 WP_004521942.1 NZ_CP111136:c449773-449477 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIADELED

Download         Length: 297 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT264869 WP_004202809.1 NZ_CP111136:c449474-449118 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References