Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3841109..3841521 Replicon chromosome
Accession NZ_CP110999
Organism Escherichia coli strain J53-p133

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag ORI88_RS18870 Protein ID WP_000132601.1
Coordinates 3841180..3841521 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3841109..3841185 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI88_RS18860 (3837972) 3837972..3839561 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
ORI88_RS18865 (3839558) 3839558..3840952 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (3841109) 3841109..3841185 - 77 NuclAT_14 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_14 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_14 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_14 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_15 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_15 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_15 - Antitoxin
- (3841109) 3841109..3841185 - 77 NuclAT_15 - Antitoxin
ORI88_RS18870 (3841180) 3841180..3841521 + 342 WP_000132601.1 endoribonuclease SymE Toxin
ORI88_RS18875 (3841683) 3841683..3843062 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
ORI88_RS18880 (3843062) 3843062..3844108 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T264733 WP_000132601.1 NZ_CP110999:3841180-3841521 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT264733 NZ_CP110999:c3841185-3841109 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References