Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 324538..324979 Replicon chromosome
Accession NC_017312
Organism Enterococcus faecalis 62

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag EF62_RS01595 Protein ID WP_002381035.1
Coordinates 324836..324979 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 324538..324736 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EF62_RS01565 319679..320671 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
EF62_RS01570 320935..321564 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
EF62_RS01580 322257..323873 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
EF62_RS01585 324203..324346 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
EF62_RS01590 324465..324605 + 141 WP_073340360.1 putative holin-like toxin -
- 324538..324736 - 199 - - Antitoxin
EF62_RS01595 324836..324979 + 144 WP_002381035.1 putative holin-like toxin Toxin
EF62_RS01600 325174..329865 - 4692 WP_010819042.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T26460 WP_002381035.1 NC_017312:324836-324979 [Enterococcus faecalis 62]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T26460 NC_017312:324836-324979 [Enterococcus faecalis 62]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 199 bp

>AT26460 NC_017312:c324736-324538 [Enterococcus faecalis 62]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References