Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3368392..3369012 Replicon chromosome
Accession NZ_CP110931
Organism Salmonella enterica strain XM3104

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag ORG44_RS16660 Protein ID WP_001280991.1
Coordinates 3368794..3369012 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag ORG44_RS16655 Protein ID WP_000344807.1
Coordinates 3368392..3368766 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG44_RS16645 (3363531) 3363531..3364724 + 1194 WP_023235518.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORG44_RS16650 (3364747) 3364747..3367896 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
ORG44_RS16655 (3368392) 3368392..3368766 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
ORG44_RS16660 (3368794) 3368794..3369012 + 219 WP_001280991.1 HHA domain-containing protein Toxin
ORG44_RS16665 (3369191) 3369191..3369742 + 552 WP_001278793.1 maltose O-acetyltransferase -
ORG44_RS16670 (3369860) 3369860..3370330 + 471 WP_000136183.1 YlaC family protein -
ORG44_RS16675 (3370386) 3370386..3370526 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
ORG44_RS16680 (3370532) 3370532..3370792 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
ORG44_RS16685 (3371017) 3371017..3372426 + 1410 WP_038393950.1 EAL domain-containing protein -
ORG44_RS16695 (3372657) 3372657..3373046 + 390 WP_000961285.1 MGMT family protein -
ORG44_RS16700 (3373079) 3373079..3373648 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T264502 WP_001280991.1 NZ_CP110931:3368794-3369012 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT264502 WP_000344807.1 NZ_CP110931:3368392-3368766 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References