Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 804269..804894 Replicon chromosome
Accession NZ_CP110931
Organism Salmonella enterica strain XM3104

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ORG44_RS03800 Protein ID WP_000911337.1
Coordinates 804269..804667 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag ORG44_RS03805 Protein ID WP_000557545.1
Coordinates 804667..804894 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG44_RS03785 (800945) 800945..801529 - 585 WP_001244638.1 fimbrial protein -
ORG44_RS03790 (802248) 802248..802880 - 633 WP_001540855.1 YfdX family protein -
ORG44_RS03795 (802927) 802927..803463 - 537 WP_001038500.1 STM3031 family outer membrane protein -
ORG44_RS03800 (804269) 804269..804667 - 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
ORG44_RS03805 (804667) 804667..804894 - 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
ORG44_RS03810 (805103) 805103..805354 + 252 WP_001540858.1 hypothetical protein -
ORG44_RS03815 (805629) 805629..806436 + 808 Protein_747 DUF1460 domain-containing protein -
ORG44_RS03825 (806721) 806721..807479 - 759 WP_000244328.1 amidase activator ActS -
ORG44_RS03830 (807744) 807744..808289 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
ORG44_RS03835 (808365) 808365..809882 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 795872..806436 10564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T264494 WP_000911337.1 NZ_CP110931:c804667-804269 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT264494 WP_000557545.1 NZ_CP110931:c804894-804667 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References