Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3013976..3014636 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q4X0
Locus tag OQO37_RS14770 Protein ID WP_017383312.1
Coordinates 3014283..3014636 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag OQO37_RS14765 Protein ID WP_017383313.1
Coordinates 3013976..3014278 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS14750 (OQO37_14750) 3010150..3011475 + 1326 WP_032619371.1 SidA/IucD/PvdA family monooxygenase -
OQO37_RS14755 (OQO37_14755) 3011502..3013691 + 2190 WP_023303946.1 TonB-dependent siderophore receptor -
OQO37_RS14765 (OQO37_14765) 3013976..3014278 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
OQO37_RS14770 (OQO37_14770) 3014283..3014636 - 354 WP_017383312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQO37_RS14775 (OQO37_14775) 3014827..3015777 - 951 WP_032619370.1 HTH-type transcriptional regulator Cbl -
OQO37_RS14780 (OQO37_14780) 3015874..3016791 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
OQO37_RS14790 (OQO37_14790) 3017323..3018255 - 933 WP_023303950.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13537.37 Da        Isoelectric Point: 9.9538

>T264383 WP_017383312.1 NZ_CP110857:c3014636-3014283 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT264383 WP_017383313.1 NZ_CP110857:c3014278-3013976 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q4X0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References