Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1115443..1116063 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag OQO37_RS05325 Protein ID WP_015571250.1
Coordinates 1115443..1115661 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag OQO37_RS05330 Protein ID WP_006809850.1
Coordinates 1115689..1116063 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS05295 (OQO37_05295) 1111455..1111715 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
OQO37_RS05300 (OQO37_05300) 1111718..1111858 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OQO37_RS05305 (OQO37_05305) 1111855..1112565 - 711 WP_023303201.1 GNAT family protein -
OQO37_RS05310 (OQO37_05310) 1112667..1114127 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
OQO37_RS05315 (OQO37_05315) 1114099..1114566 - 468 WP_017383209.1 YlaC family protein -
OQO37_RS05320 (OQO37_05320) 1114683..1115234 - 552 WP_023303203.1 maltose O-acetyltransferase -
OQO37_RS05325 (OQO37_05325) 1115443..1115661 - 219 WP_015571250.1 HHA domain-containing protein Toxin
OQO37_RS05330 (OQO37_05330) 1115689..1116063 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
OQO37_RS05335 (OQO37_05335) 1116574..1119720 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
OQO37_RS05340 (OQO37_05340) 1119743..1120936 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T264376 WP_015571250.1 NZ_CP110857:c1115661-1115443 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT264376 WP_006809850.1 NZ_CP110857:c1116063-1115689 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References