Detailed information of TA system TA026434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1781680..1782273
• Replicon: chromosome
• Accession: NC_017310
• Organism: Desulfovibrio vulgaris RCH1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q72BA7
• Locus tag: DEVAL_RS07850
• Protein ID: WP_010939017.1
• Coordinates: 1781995..1782273 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DEVAL_RS07845
• Protein ID: WP_010939018.1
• Coordinates: 1781680..1781985 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEVAL_RS07835	1776936..1777130	-	195	WP_010939024.1	hypothetical protein	-
DEVAL_RS16870	1777114..1777257	-	144	WP_010939023.1	BrnT family toxin	-
DEVAL_RS18650	1777278..1781078	-	3801	WP_014524399.1	hypothetical protein	-
DEVAL_RS07845	1781680..1781985	-	306	WP_010939018.1	HigA family addiction module antidote protein	Antitoxin
DEVAL_RS07850	1781995..1782273	-	279	WP_010939017.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DEVAL_RS07855	1782544..1782960	+	417	WP_010939016.1	hypothetical protein	-
DEVAL_RS07860	1782960..1783310	+	351	WP_010939015.1	hypothetical protein	-
DEVAL_RS07865	1783307..1783555	+	249	WP_010939014.1	hypothetical protein	-
DEVAL_RS07870	1783691..1784299	+	609	WP_010939013.1	hypothetical protein	-
DEVAL_RS07875	1784286..1785890	+	1605	WP_010939012.1	hypothetical protein	-
DEVAL_RS07880	1785887..1786441	+	555	WP_010939011.1	hypothetical protein	-
DEVAL_RS07885	1786438..1786791	+	354	WP_010939010.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10558.00 Da
• Isoelectric Point: 7.8928

>T26434 WP_010939017.1 NC_017310:c1782273-1781995 [Desulfovibrio vulgaris RCH1]
MIASFRCKETRSLFDGGTSRRFQAFSAVALRKLDMLDAAVSLDDLRIPPANRLEALKGDRQGQHSIRINDQWRVCFVWRD
GAPHDVEIVDYH

Nucleotide

• Length: 279 bp

>T26434 NC_017310:c1782273-1781995 [Desulfovibrio vulgaris RCH1]
ATGATAGCGTCATTCCGCTGTAAGGAGACCCGCAGCCTTTTCGACGGCGGCACGAGCCGTCGCTTTCAGGCGTTCTCCGC
AGTGGCCCTGCGCAAGCTCGACATGCTCGATGCGGCGGTAAGCCTGGACGACCTGCGCATTCCCCCCGCGAACCGGCTCG
AAGCCCTCAAGGGCGACAGGCAAGGGCAACACAGCATCCGCATCAACGACCAGTGGCGTGTGTGCTTTGTCTGGCGCGAT
GGCGCACCGCATGACGTGGAAATCGTCGACTACCACTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10893.47 Da
• Isoelectric Point: 9.2414

>AT26434 WP_010939018.1 NC_017310:c1781985-1781680 [Desulfovibrio vulgaris RCH1]
MRIRTHPGEVLNEEFLKPLGVTAHALAVALGVPATRIADIVHQRRGVSADTAARLARFFGTSAAFWMNLQSAYDLSIVER
DKGADLSHIRPHASVGTSLSC

Nucleotide

• Length: 306 bp

>AT26434 NC_017310:c1781985-1781680 [Desulfovibrio vulgaris RCH1]
ATGCGCATTCGCACCCACCCGGGCGAAGTCCTGAACGAAGAGTTCCTCAAGCCGCTTGGCGTCACCGCCCATGCTCTGGC
AGTGGCCCTTGGCGTACCGGCCACCCGCATCGCAGACATCGTGCACCAGCGGCGCGGCGTCTCTGCGGATACGGCAGCCC
GCCTCGCGCGCTTCTTCGGCACCAGTGCGGCATTCTGGATGAACCTTCAGTCGGCCTATGACCTTTCCATCGTCGAGCGC
GACAAGGGGGCCGACCTCTCGCACATCCGCCCGCACGCCAGCGTGGGCACTTCCCTCTCGTGCTGA

Structures

Toxin

• AlphaFold DB: Q72BA7