Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 253200..253796 Replicon chromosome
Accession NZ_CP110534
Organism Enterobacter roggenkampii strain WS28-4

Toxin (Protein)


Gene name PumA Uniprot ID A0A837YNH1
Locus tag OM420_RS01120 Protein ID WP_049121167.1
Coordinates 253494..253796 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag OM420_RS01115 Protein ID WP_021242718.1
Coordinates 253200..253487 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM420_RS01110 (OM420_01110) 251572..253203 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
OM420_RS01115 (OM420_01115) 253200..253487 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
OM420_RS01120 (OM420_01120) 253494..253796 - 303 WP_049121167.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM420_RS01125 (OM420_01125) 253994..254866 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
OM420_RS01130 (OM420_01130) 254867..255139 - 273 WP_014830263.1 DUF3811 domain-containing protein -
OM420_RS01135 (OM420_01135) 255190..256134 - 945 WP_277695881.1 ketopantoate/pantoate/pantothenate transporter PanS -
OM420_RS01140 (OM420_01140) 256240..257814 - 1575 WP_039024657.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11486.26 Da        Isoelectric Point: 10.1771

>T263940 WP_049121167.1 NZ_CP110534:c253796-253494 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLNNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT263940 WP_021242718.1 NZ_CP110534:c253487-253200 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837YNH1

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References