Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4667293..4668551 Replicon chromosome
Accession NZ_CP110353
Organism Pseudomonas aeruginosa strain PALA48

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA48_RS21900 Protein ID WP_012614407.1
Coordinates 4667293..4668048 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA48_RS21905 Protein ID WP_003086329.1
Coordinates 4668183..4668551 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA48_RS21890 (PALA48_04353) 4662466..4665009 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA48_RS21895 (PALA48_04354) 4665164..4666525 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA48_RS21900 (PALA48_04355) 4667293..4668048 - 756 WP_012614407.1 RES family NAD+ phosphorylase Toxin
PALA48_RS21905 (PALA48_04356) 4668183..4668551 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA48_RS21910 (PALA48_04357) 4668624..4669910 - 1287 WP_012614408.1 FAD-binding oxidoreductase -
PALA48_RS21915 (PALA48_04358) 4669966..4671555 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA48_RS21920 (PALA48_04359) 4671634..4672110 + 477 WP_003112531.1 hypothetical protein -
PALA48_RS21925 4672113..4672388 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T263695 WP_012614407.1 NZ_CP110353:c4668048-4667293 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263695 WP_003086329.1 NZ_CP110353:c4668551-4668183 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References