Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3755676..3756897 | Replicon | chromosome |
| Accession | NZ_CP110353 | ||
| Organism | Pseudomonas aeruginosa strain PALA48 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA48_RS17590 | Protein ID | WP_012614272.1 |
| Coordinates | 3756319..3756897 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA48_RS17585 | Protein ID | WP_003088112.1 |
| Coordinates | 3755676..3756230 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA48_RS17560 (PALA48_03486) | 3751244..3751795 | + | 552 | WP_004343115.1 | XRE family transcriptional regulator | - |
| PALA48_RS17565 (PALA48_03487) | 3751792..3752190 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA48_RS17570 (PALA48_03488) | 3752203..3752526 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA48_RS17575 (PALA48_03489) | 3752857..3753318 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA48_RS17580 (PALA48_03490) | 3753323..3755518 | + | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA48_RS17585 (PALA48_03491) | 3755676..3756230 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA48_RS17590 (PALA48_03492) | 3756319..3756897 | + | 579 | WP_012614272.1 | HD domain-containing protein | Toxin |
| PALA48_RS17595 (PALA48_03493) | 3756934..3758121 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA48_RS17600 (PALA48_03494) | 3758111..3760282 | - | 2172 | WP_012614273.1 | type I secretion system permease/ATPase | - |
| PALA48_RS17605 (PALA48_03495) | 3760272..3761549 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T263694 WP_012614272.1 NZ_CP110353:3756319-3756897 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLASLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLASLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT263694 WP_003088112.1 NZ_CP110353:3755676-3756230 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|