Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5671876..5672471 Replicon chromosome
Accession NZ_CP110346
Organism Pseudomonas aeruginosa strain PALA35

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA35_RS26380 Protein ID WP_003113526.1
Coordinates 5672193..5672471 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA35_RS26375 Protein ID WP_031638452.1
Coordinates 5671876..5672181 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA35_RS26340 (PALA35_05214) 5667017..5667865 + 849 WP_058166986.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA35_RS26350 (PALA35_05216) 5668032..5668973 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA35_RS26355 (PALA35_05217) 5669090..5669704 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PALA35_RS26360 (PALA35_05218) 5669746..5670330 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA35_RS26365 (PALA35_05219) 5670371..5671471 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA35_RS26375 (PALA35_05221) 5671876..5672181 - 306 WP_031638452.1 HigA family addiction module antitoxin Antitoxin
PALA35_RS26380 5672193..5672471 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA35_RS26385 5672524..5672652 - 129 Protein_5214 integrase -
PALA35_RS26390 (PALA35_05222) 5672800..5675028 + 2229 WP_269974514.1 TonB-dependent receptor -
PALA35_RS26395 (PALA35_05223) 5675098..5675745 - 648 WP_003095021.1 carbonate dehydratase -
PALA35_RS26400 (PALA35_05224) 5675807..5677045 - 1239 WP_023107901.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T263651 WP_003113526.1 NZ_CP110346:c5672471-5672193 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11156.70 Da        Isoelectric Point: 4.7860

>AT263651 WP_031638452.1 NZ_CP110346:c5672181-5671876 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELGISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References