Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 31401..32068 Replicon plasmid pA
Accession NZ_CP110302
Organism Xanthomonas citri pv. fuscans strain CFBP 6533

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag OM953_RS22150 Protein ID WP_022557732.1
Coordinates 31401..31817 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag OM953_RS22155 Protein ID WP_022557731.1
Coordinates 31814..32068 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM953_RS22125 (OM953_22125) 27131..28450 + 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -
OM953_RS22130 (OM953_22130) 28577..29869 + 1293 WP_033481893.1 M12 family metallo-peptidase -
OM953_RS22135 (OM953_22135) 30024..30572 + 549 WP_022557734.1 DNA topoisomerase -
OM953_RS22140 (OM953_22140) 30621..30758 + 138 Protein_32 transposase -
OM953_RS22145 (OM953_22145) 30833..31387 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
OM953_RS22150 (OM953_22150) 31401..31817 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
OM953_RS22155 (OM953_22155) 31814..32068 - 255 WP_022557731.1 plasmid stability protein Antitoxin
OM953_RS22160 (OM953_22160) 32280..32873 + 594 WP_022560487.1 recombinase family protein -
OM953_RS22165 (OM953_22165) 32870..35899 + 3030 WP_022560486.1 Tn3 family transposase -
OM953_RS22170 (OM953_22170) 35932..36890 + 959 Protein_38 IS3-like element ISXcd1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57070 57070
- inside IScluster/Tn - - 30621..36890 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T263596 WP_022557732.1 NZ_CP110302:c31817-31401 [Xanthomonas citri pv. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT263596 WP_022557731.1 NZ_CP110302:c32068-31814 [Xanthomonas citri pv. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References