Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4417451..4418232 Replicon chromosome
Accession NZ_CP110201
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OCK73_RS21590 Protein ID WP_000626099.1
Coordinates 4417451..4417942 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OCK73_RS21595 Protein ID WP_001110452.1
Coordinates 4417939..4418232 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK73_RS21550 (4412637) 4412637..4412879 - 243 WP_197603740.1 hypothetical protein -
OCK73_RS21555 (4412876) 4412876..4413232 - 357 WP_033567083.1 hypothetical protein -
OCK73_RS21560 (4413229) 4413229..4414101 - 873 WP_033567082.1 ParA family protein -
OCK73_RS21565 (4414292) 4414292..4414369 - 78 Protein_4217 helix-turn-helix domain-containing protein -
OCK73_RS21570 (4414460) 4414460..4414792 - 333 WP_001165471.1 MerR family transcriptional regulator -
OCK73_RS21575 (4414864) 4414864..4415241 + 378 WP_000916345.1 EthD family reductase -
OCK73_RS21580 (4416274) 4416274..4416348 + 75 Protein_4220 porin family protein -
OCK73_RS21585 (4416451) 4416451..4417203 + 753 WP_000842434.1 non-specific acid phosphatase -
OCK73_RS21590 (4417451) 4417451..4417942 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OCK73_RS21595 (4417939) 4417939..4418232 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OCK73_RS21600 (4418549) 4418549..4418770 + 222 WP_001576552.1 hypothetical protein -
OCK73_RS21605 (4419035) 4419035..4419910 + 876 WP_000921674.1 AraC family transcriptional regulator -
OCK73_RS21610 (4419907) 4419907..4420194 + 288 WP_001269916.1 transcriptional regulator RtsB -
OCK73_RS21615 (4420217) 4420217..4420432 + 216 WP_001595136.1 hypothetical protein -
OCK73_RS21620 (4420440) 4420440..4420709 + 270 WP_010989096.1 hypothetical protein -
OCK73_RS21625 (4421003) 4421003..4421908 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T263426 WP_000626099.1 NZ_CP110201:c4417942-4417451 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT263426 WP_001110452.1 NZ_CP110201:c4418232-4417939 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References