Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2156061..2156257 Replicon chromosome
Accession NC_017174
Organism Clostridium difficile M120

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag CDM120_RS19615 Protein ID WP_003424190.1
Coordinates 2156105..2156257 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2156061..2156161 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDM120_RS10245 2151328..2151585 - 258 WP_003424182.1 hypothetical protein -
CDM120_RS10250 2151572..2151805 - 234 WP_003424184.1 hypothetical protein -
CDM120_RS10255 2151993..2152181 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
- 2156061..2156161 + 101 NuclAT_0 - Antitoxin
CDM120_RS19615 2156105..2156257 - 153 WP_003424190.1 hypothetical protein Toxin
CDM120_RS19725 2157085..2157630 + 546 WP_077699404.1 site-specific integrase -
CDM120_RS10275 2158175..2159021 + 847 Protein_1932 DUF4878 domain-containing protein -
CDM120_RS19625 2159245..2159409 - 165 WP_003424195.1 hypothetical protein -
CDM120_RS19345 2159941..2160272 - 332 Protein_1934 carboxymuconolactone decarboxylase family protein -
CDM120_RS10290 2160532..2161173 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T26334 WP_003424190.1 NC_017174:c2156257-2156105 [Clostridioides difficile M120]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T26334 NC_017174:c2156257-2156105 [Clostridioides difficile M120]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT26334 NC_017174:2156061-2156161 [Clostridioides difficile M120]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References