Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2665151..2666739 Replicon chromosome
Accession NZ_CP110170
Organism Klebsiella pneumoniae strain YZ22PK089

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OK017_RS13200 Protein ID WP_263598315.1
Coordinates 2665151..2666473 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OK017_RS13205 Protein ID WP_004176198.1
Coordinates 2666473..2666739 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK017_RS13185 (2660207) 2660207..2662708 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
OK017_RS13190 (2662696) 2662696..2663700 + 1005 WP_064151581.1 fimbrial protein -
OK017_RS13195 (2663842) 2663842..2665134 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OK017_RS13200 (2665151) 2665151..2666473 - 1323 WP_263598315.1 type II toxin-antitoxin system HipA family toxin Toxin
OK017_RS13205 (2666473) 2666473..2666739 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OK017_RS13210 (2667005) 2667005..2667331 - 327 WP_004176200.1 hydroxyisourate hydrolase -
OK017_RS13215 (2667328) 2667328..2667828 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OK017_RS13220 (2667806) 2667806..2669185 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OK017_RS13225 (2669531) 2669531..2670685 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OK017_RS13230 (2670666) 2670666..2671589 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49194.50 Da        Isoelectric Point: 7.2850

>T263337 WP_263598315.1 NZ_CP110170:c2666473-2665151 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQVATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT263337 WP_004176198.1 NZ_CP110170:c2666739-2666473 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References