Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2731499..2733087 Replicon chromosome
Accession NZ_CP110142
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag OMD37_RS13670 Protein ID WP_004892016.1
Coordinates 2731499..2732821 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OMD37_RS13675 Protein ID WP_004176198.1
Coordinates 2732821..2733087 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS13655 (2726555) 2726555..2729056 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
OMD37_RS13660 (2729044) 2729044..2730048 + 1005 WP_032435338.1 fimbrial protein -
OMD37_RS13665 (2730190) 2730190..2731482 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OMD37_RS13670 (2731499) 2731499..2732821 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
OMD37_RS13675 (2732821) 2732821..2733087 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OMD37_RS13680 (2733474) 2733474..2733800 - 327 WP_004184023.1 hydroxyisourate hydrolase -
OMD37_RS13685 (2733797) 2733797..2734297 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OMD37_RS13690 (2734275) 2734275..2735654 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OMD37_RS13695 (2736000) 2736000..2737154 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OMD37_RS13700 (2737135) 2737135..2738058 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T263207 WP_004892016.1 NZ_CP110142:c2732821-2731499 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT263207 WP_004176198.1 NZ_CP110142:c2733087-2732821 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References