Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3264961..3265654 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag OLR74_RS16090 Protein ID WP_282983233.1
Coordinates 3265358..3265654 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OLR74_RS16085 Protein ID WP_000650107.1
Coordinates 3264961..3265356 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS16075 (3260825) 3260825..3263083 - 2259 WP_255784241.1 DNA topoisomerase IV subunit A -
OLR74_RS16080 (3263221) 3263221..3264828 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OLR74_RS16085 (3264961) 3264961..3265356 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OLR74_RS16090 (3265358) 3265358..3265654 - 297 WP_282983233.1 type II toxin-antitoxin system toxin MqsR Toxin
OLR74_RS16095 (3265859) 3265859..3266341 - 483 WP_000183505.1 GyrI-like domain-containing protein -
OLR74_RS16100 (3266394) 3266394..3266786 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OLR74_RS16105 (3266938) 3266938..3267597 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
OLR74_RS16110 (3267594) 3267594..3268943 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
OLR74_RS16115 (3268989) 3268989..3269321 - 333 WP_000917684.1 DUF2645 family protein -
OLR74_RS16120 (3269640) 3269640..3270221 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OLR74_RS16125 (3270252) 3270252..3270566 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11245.99 Da        Isoelectric Point: 8.9070

>T262704 WP_282983233.1 NZ_CP110016:c3265654-3265358 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSEHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262704 WP_000650107.1 NZ_CP110016:c3265356-3264961 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References