262589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880410..4880926 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OI501_RS24160 Protein ID WP_002886902.1
Coordinates 4880410..4880694 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OI501_RS24165 Protein ID WP_002886901.1
Coordinates 4880684..4880926 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS24135 (OI501_24140) 4875894..4876157 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OI501_RS24140 (OI501_24145) 4876287..4876460 + 174 WP_002886906.1 hypothetical protein -
OI501_RS24145 (OI501_24150) 4876463..4877206 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OI501_RS24150 (OI501_24155) 4877563..4879701 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OI501_RS24155 (OI501_24160) 4879942..4880406 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OI501_RS24160 (OI501_24165) 4880410..4880694 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI501_RS24165 (OI501_24170) 4880684..4880926 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OI501_RS24170 (OI501_24175) 4881004..4882914 - 1911 WP_004152270.1 PRD domain-containing protein -
OI501_RS24175 (OI501_24180) 4882937..4884091 - 1155 WP_002886900.1 lactonase family protein -
OI501_RS24180 (OI501_24185) 4884157..4884897 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T262589 WP_002886902.1 NZ_CP109973:c4880694-4880410 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT262589 WP_002886901.1 NZ_CP109973:c4880926-4880684 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References