262580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884938..885592 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OI501_RS04470 Protein ID WP_004144731.1
Coordinates 885185..885592 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OI501_RS04465 Protein ID WP_002916312.1
Coordinates 884938..885204 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS04440 (OI501_04440) 880094..881527 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OI501_RS04445 (OI501_04445) 881646..882374 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OI501_RS04450 (OI501_04450) 882424..882735 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OI501_RS04455 (OI501_04455) 882899..883558 + 660 WP_002916317.1 hemolysin III family protein -
OI501_RS04460 (OI501_04460) 883709..884692 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OI501_RS04465 (OI501_04465) 884938..885204 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OI501_RS04470 (OI501_04470) 885185..885592 + 408 WP_004144731.1 protein YgfX Toxin
OI501_RS04475 (OI501_04475) 885599..886120 - 522 WP_002916308.1 flavodoxin FldB -
OI501_RS04480 (OI501_04480) 886221..887117 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OI501_RS04485 (OI501_04485) 887140..887853 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OI501_RS04490 (OI501_04490) 887859..889592 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T262580 WP_004144731.1 NZ_CP109973:885185-885592 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T262580 NZ_CP109973:885185-885592 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT262580 WP_002916312.1 NZ_CP109973:884938-885204 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT262580 NZ_CP109973:884938-885204 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A378E4P6


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References