Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3002020..3002615 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag OI124_RS14550 Protein ID WP_000239579.1
Coordinates 3002020..3002370 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OI124_RS14555 Protein ID WP_001223208.1
Coordinates 3002364..3002615 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS14530 (2997280) 2997280..2998302 - 1023 WP_001339490.1 ABC transporter permease -
OI124_RS14535 (2998316) 2998316..2999818 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
OI124_RS14540 (3000128) 3000128..3001100 - 973 Protein_2839 galactofuranose ABC transporter substrate-binding protein YtfQ -
OI124_RS14545 (3001410) 3001410..3001940 + 531 WP_000055072.1 inorganic diphosphatase -
OI124_RS14550 (3002020) 3002020..3002370 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
OI124_RS14555 (3002364) 3002364..3002615 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OI124_RS14560 (3002828) 3002828..3003169 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OI124_RS14565 (3003172) 3003172..3006951 - 3780 WP_048943320.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T262528 WP_000239579.1 NZ_CP109953:c3002370-3002020 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT262528 WP_001223208.1 NZ_CP109953:c3002615-3002364 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References