Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4640261..4640942 Replicon chromosome
Accession NZ_CP109919
Organism Pseudomonas aeruginosa strain PALA56

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag PALA56_RS21695 Protein ID WP_003111825.1
Coordinates 4640577..4640942 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag PALA56_RS21690 Protein ID WP_003159602.1
Coordinates 4640261..4640584 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA56_RS21655 (PALA56_04311) 4636220..4636903 - 684 WP_003120766.1 TetR/AcrR family transcriptional regulator -
PALA56_RS21660 (PALA56_04312) 4636991..4637869 + 879 WP_014603214.1 hypothetical protein -
PALA56_RS21670 4638472..4638699 + 228 WP_014603215.1 hypothetical protein -
PALA56_RS21675 4638714..4639639 - 926 Protein_4286 tyrosine-type recombinase/integrase -
PALA56_RS21680 (PALA56_04315) 4639639..4640031 - 393 Protein_4287 hypothetical protein -
PALA56_RS21685 4640026..4640145 + 120 Protein_4288 IS5/IS1182 family transposase -
PALA56_RS21690 (PALA56_04316) 4640261..4640584 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
PALA56_RS21695 4640577..4640942 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA56_RS21700 4641233..4641407 - 175 Protein_4291 hypothetical protein -
PALA56_RS21705 (PALA56_04317) 4641614..4641886 + 273 WP_014603216.1 hypothetical protein -
PALA56_RS21710 (PALA56_04318) 4641916..4642341 - 426 WP_003116492.1 VOC family protein -
PALA56_RS21715 (PALA56_04319) 4642442..4643326 + 885 WP_003085663.1 LysR substrate-binding domain-containing protein -
PALA56_RS21720 (PALA56_04320) 4643299..4644252 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA56_RS21725 (PALA56_04321) 4644473..4644907 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T262340 WP_003111825.1 NZ_CP109919:c4640942-4640577 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT262340 WP_003159602.1 NZ_CP109919:c4640584-4640261 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References