Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1922208..1922710 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name yoeB Uniprot ID V0THH9
Locus tag NQ150_RS09100 Protein ID WP_023141665.1
Coordinates 1922456..1922710 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NQ150_RS09095 Protein ID WP_001259255.1
Coordinates 1922208..1922459 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS09070 (1917386) 1917386..1918453 - 1068 WP_033865586.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NQ150_RS09075 (1918453) 1918453..1919523 - 1071 WP_033865585.1 histidinol-phosphate transaminase -
NQ150_RS09080 (1919520) 1919520..1920824 - 1305 WP_033865584.1 histidinol dehydrogenase -
NQ150_RS09085 (1920830) 1920830..1921729 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NQ150_RS09090 (1921875) 1921875..1921925 - 51 WP_001364200.1 his operon leader peptide -
NQ150_RS09095 (1922208) 1922208..1922459 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NQ150_RS09100 (1922456) 1922456..1922710 + 255 WP_023141665.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NQ150_RS09105 (1922793) 1922793..1923617 + 825 WP_000754758.1 SDR family oxidoreductase -
NQ150_RS09110 (1923663) 1923663..1924592 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NQ150_RS09115 (1924807) 1924807..1924869 + 63 WP_010723108.1 membrane protein YoeI -
NQ150_RS09120 (1924859) 1924859..1926217 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NQ150_RS09125 (1926396) 1926396..1927454 + 1059 WP_029397759.1 thiosulfate utilization transporter TsuA/YeeE -
NQ150_RS09130 (1927468) 1927468..1927695 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.67 Da        Isoelectric Point: 7.8733

>T262245 WP_023141665.1 NZ_CP109874:1922456-1922710 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFECKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT262245 WP_001259255.1 NZ_CP109874:1922208-1922459 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0THH9

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References